Aspscr1 126304-Aspscr1

ASPSCR1 is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells, and redistributes the GLUT4 to the plasma membrane Translocation t(X;17)(p11;q25) of this ASPSCR1 with transcription factor TF gene ends with a ASPSCR1TF fusion protein in alveolar soft part sarcoma and in renal cell carcinomas Description ASPSCR1 Human RecombinantNCBI Description of ASPSCR1 The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation TranslocationContains an UBX domain, which

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Aspscr1

Aspscr1- ASPSCR1 470 Annotation score Annotation score1 out of 5 The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given proteinASPSCR1 controls VCP oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types ;

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31 ASPSCR1 Silencer Select Predesigned, Validated, and Custom siRNA in Standard, HPLC, and Invivo Ready PuritiesSIRT2 binds and deacetylates ASPSCR1 ;ASPSCR1 Name ASPSCR1 tether for SLC2, UBX domain containing Synonyms A A306_ alveolar soft part sarcoma chromosomal region candidate gene 1 protein alveolar soft part sarcoma chromosomal region candidate gene 1 protein

ASPSCR1 (arrow) was detected using the purified antibody ASPSCR1 Antibody flow cytometry of HeLa cells (right histogram) compared to a negative control cell (left histogram) FITCconjugated goatantirabbit secondary antibodies were used for the analysis quantity price to the supplier UBXD9 / ASPL Antibody (aa) LSC LifeSpan Biosciences catalog LSCThese include ASPSCR1TF in all cases of alveolar soft part sarcoma (ASPS) and ASPSCR1TF, PRCCTF, SFPQTF and others in a subset of paediatric and adult RCCs Here we examined the functi Combining integrated genomics and functional genomics to dissect the biology of a cancerassociated, aberrant transcription factor, the ASPSCR1TF fusionCreative diagnostics provides ASPSCR1 antibodies and elisa kits for science research use, feel free to contact us

OncoKB is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancerASPSCR1 tether for SLC2, UBX domain containing Aliases TUG, ASPL, ASPS, RCC17, UBXD9, UBXN9, ASPCR1 Location 17q253 Summary The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in theASPSCR1 (Alveolar soft part sarcoma critical region 1) alveolar soft part sarcoma chromosome region, candidate 1 Starts at and ends at bp from pter ( according to GRCh38/hg38Dec_13) Mapping ASPSCR1png alternative splicing of 47 bp from exon 2 in the 5' untranslated region 476 amino acids;

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Molecular confirmation of ASPSCR1TF gene fusion is applicable to routinely processed archival and diagnostic tumour samples and aids in the differential diagnosis of ASPS Detection of the ASPSCR1TF gene fusion in paraffinembedded alveolar soft part sarcomas Histopathology 07 Jun;50(7)16 doi /jx Authors S Aulmann 1 , TASPSCR1 is altered in 011% of all cancers with alveolar soft part sarcoma, translocationassociated renal cell carcinoma, high grade ovarian serous adenocarcinoma, endometrial endometrioid adenocarcinoma, and unknown having the greatest prevalence of alterationsIt sequesters GLUT4containing vesicles in the cytoplasm in absence of insulin

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ASPSCR1 A gene on chromosome 17q253 that encodes a ubiquitous tethering protein highly expressed in the testes, heart, skeletal muscle and pancreas;ASPSCR1 acetylation promotes SLC2 accumulation in an intracellular, insulinresponsive compartment ;ASPSCR1 ( 1 gene ) Coverage 99% at x Specimen Requirements Blood (two 4ml EDTA tubes, lavender top) or Extracted DNA (3ug in EB buffer) or Buccal Swab or Saliva (kits available upon request) Test Limitations All sequencing technologies have limitations This analysis is performed by Next Generation Sequencing (NGS) and is designed to examine coding regions and splicing

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 Plasmid construction Nterminal FLAGtagged ASPSCR1TF was introduced into both the pMYsIRESGFP and pMYsIRESLuc vectors The fulllength ASPSCR1TF was cloned from a human ASPS case Artificial chimeric ASPSCR1 fusions between ASPSCR1 and TFEB, TFEC, or MITF were also generated by twostep PCR using primers encompassing both ASPSCR1 andTranslocation t(X;17)(p11;q25) of this gene with transcription factor TF gene results in a ASPSCR1TF fusion protein in alveolar soft part sarcoma and in renal cell carcinomas Multiple alternatively spliced transcript variants have been found provided by RefSeq, Oct 11 Uniprot Accession IDs Q9BZE9 open_in_new A8K3K9 open_in_new Q7Z6N7 open_in_new Q8WV59 ASPSCR1 expression was also found in all cancer cell lines tested Independently, Heimann et al (01) identified the ASPSCR1 gene, which they called RCC17, partnered with TF in two 5yearold Belgian girls of African origin in whom papillary renal cell carcinomas () carried the translocation t(X;17)(p112;q25) In both patients, the t

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AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by coalignment and clustering of all publicly available mRNAs and ESTs on the genome sequence Our goals are to offer a reliable uptodate resource on the genes, their functions, alternative variants, expression, regulation and interactions, in the hope to stimulate further validatingASPSCR1 gene product ASPL, ASPS, TUG, UBXD9, UBXN9 The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membraneAspscr1 ID ZDBGENE Name ASPSCR1 tether for SLC2, UBX domain containing Symbol aspscr1 Nomenclature History Previous Names zgc;

Aspscr1 Wikipedia

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 The ASPSCR1TF translocation in ASPS is identical to the ASPSCR1TF fusion seen in secondary Xp11 translocation RCC Xp11 translocation RCC was first officially recognized by the World Health Organization in 04 and these tumors bear chromosome translocations that result in gene fusions involving the TF gene, which maps to the Xp112 locus Argani et al3 ASPSCR1 TEXT A number sign (#) is used with this entry because some cases of alveolar soft part sarcoma have been found to be caused by fusion of the ASPSCR1 () and TF () genes Description Alveolar soft part sarcoma is an unusual tumor with highly characteristic histopathology and ultrastructureDéfinitions de aspscr1, synonymes, antonymes, dérivés de aspscr1, dictionnaire analogique de aspscr1 (anglais)

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Creative Biolabs can provide AntiASPSCR1 Aptamer Complement Function/Activity Test Complement function or activity test allows for the determination of whether the protein is present and whether it has normal functional activity A wide range of assays are now available in Creative Biolabs, such as Hemolysis assays (CH50 or AH50), Elisa Assays (c3a, c5a, FH, FB, C5b9 or The ASPSCR1TF and ASPSCR1TFEB but not ASPSCR1TFEC and ASPSCR1MITF induced sarcoma The results suggest the presence of TF/TFEBspecific cofactors and mechanisms for tumorigenesis In order to identify such novel cofactors and functional motifs, human ASPS cellnuclear extract was incubated with TF or MITF proteins and TF or MITFGENERAL INFORMATIONi General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project Gene namei Official gene symbol, which is typically a short form of the gene name, according to HGNC ASPSCR1

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ASPSCR1 is fused in frame to TF exon 3 or 4 the reciprocal 5' TF 3' ASPSCR1 may or may not be transcribed Fusion Protein Description NH2 term from ASPSCR1, fused to the C term of TF, including the activation domain, the helixloophelix, and the leucine zipper from TF Bibliography Primary renal neoplasms with the ASPLTF gene fusion of alveolar soft partASPSCR1TF fusion protein regulates cell cycle progression Alveolar soft part sarcoma (ASPS) is an exceptionally rare nonrhabdomyosarcomatous soft tissue sarcoma (NRSTS), characterized by the translocation t(X;17) p(112;q25) This translocation results i

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VCP ASPSCR1 Affinity CaptureLuminescence Affinity CaptureLuminescence An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag Arumughan A (16) LowBioGRID ASPSCR1Aspscr1 Addgene Alerts Receive email alerts when new plasmids with this gene become available Log in to subscribe to Addgene Alerts Description alveolar soft part sarcoma chromosome region, candidate 1 (human) Also known as K01Rik, ASPC, ASPCR1, ASPL, ASPS, RCC17, TUG Species Mus musculus EntrezASPSCR1 ASPCR1, ASPL, ASPS, RCC17, TUG, UBXD9, UBXN9 alveolar soft part sarcoma chromosome region, candidate 1 GO Process (1) GO Function (1) GO Component (3) Gene Ontology Biological Process membrane organization Gene Ontology Molecular Function protein binding Gene Ontology Cellular Component intracellular membranebounded organelle ;

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ASPSCR1 has 4,6 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 77 datasets Click the buttons to view associations for ASPSCR1 from the datasets below IfASPSCR1 (ASPL, ASPS, TUG, UBXD9, UBXN9) Tissue specificityi The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5 The categories include tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected ASPSCR1TF fusion and several somatic copy number alterations, including the loss of 22q, are associated with aggressive features and poor outcomes Apart from tumors with MED15TF fusion

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Aspscr1 53 Annotation score There are more potential isoformsShow all Experimental Info Feature key Position(s) Description Actions Graphical view Length;Showing 25 of 2,075 Results for ASPSCR1 Search Time 0 ms Showing of 2,075 Results for ASPSCR1 Search Time 0 ms Export Show Symbol Description Category GIFtS GC id Score;Other interactions of ASPSCR1 The der (17)t (X;17) (p11;q25) of human alveolar soft part sarcoma fuses the TF transcription factor gene to ASPL, a novel gene at 17q25 8 The status of the TP53 alleles was followed at different stages by fluorescence in situ hybridization (FISH) and allelespecific PCR ( ASPCR) on total DNA, as well as flow

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Aspscr1 Wikipedia

Description Homo sapiens ASPSCR1 tether for SLC2, UBX domain containing (ASPSCR1), transcript variant 2, mRNA (from RefSeq NM_) RefSeq Summary (NM_) The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4) This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscleView mouse Aspscr1 Chr with phenotypes, sequences, polymorphisms, proteins, references, function, expressionASPSCR1_ENST, ASPSCR1_ENST, ASPSCR1_ENST Sequences You can see various sequences for this gene cDNA (ENST) Protein (ASPSCR1) Transcript and protein aligned (ENSTASPSCR1) Gene fusions ASPSCR1 is involved in 1 fusion, with the following gene

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Western blot analysis of extracts of various cell lines, using TUG/ASPSCR1 antibody (481) at dilution Secondary antibody HRP Goat AntiRabbit IgG (HL) (AS014) at dilution Lysates/proteins 25ug per lane Blocking buffer 3% nonfat dry milk in TBST Detection ECL Basic Kit (RM000) Exposure time 30s Immunoprecipitation analysis of 0ug extracts of A5491 ASPSCR1 ASPSCR1 Tether For SLC2, UBX Domain Containing Protein Coding 41 GC17P 47 2 TF Transcription Factor Binding To IGHM Enhancer 3 ASPSCR1 (ASPSCR1 Tether For SLC2, UBX Domain Containing) is a Protein Coding gene Diseases associated with ASPSCR1 include Alveolar Soft Part Sarcoma and Renal Cell Carcinoma, Xp11AssociatedAmong its related pathways are Vesiclemediated transport and Translocation of GLUT4 to the plasma membrane

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 A conditional expression in mice of the fusion gene ASPSCR1TF from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile ASPL is a cofactor of the hexameric ATPase complex, known as p97 The central area in ASPL, containing both a SHP box and a UBX domain, isSynonyms for ASPSCR1 in Free Thesaurus Antonyms for ASPSCR1 54 synonyms for tug pull, drag, pluck, jerk, yank, wrench, lug, drag, pull, haul, tow, lug, heave, drawASPSCR1 Hallmarks of Cancer Explore the role of ASPSCR1 in cancer within the context of the hallmarks behaviours and functional descriptions ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1

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Aspscr1 Human

Type protein_coding_gene Location Chr 11 Mapping Details/Browsers Description Human ortholog(s) of this gene implicated in alveolar soft part sarcoma Orthologous to human ASPSCR1 (ASPSCR1 tether for SLC2, UBXASPSCR1 synonyms, ASPSCR1 pronunciation, ASPSCR1 translation, English dictionary definition of ASPSCR1 v tugged , tug·ging , tugs v tr 1 To pull at vigorously or repeatedly tugged the bell rope See Synonyms at pull 2 To move by pulling with great

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